Browse>5IY6:T

Detailed Infomation


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  • PDB: 5IY6

  • Chain: T

  • Protein Name: General transcription factor IIF subunit 2

  • GeneName: GTF2F2

  • Resolution: 7.2 Å
  •        Method: X-RAY DIFFRACTION
PTM Information
PDBChain PTM Type PTM Position
in PDBChain
UniProt ACC PTM Position UniProtID Organism
5IY6:T Acetylation_A 2 P13984 2 T2FB_HUMAN Homo sapiens (Human)
5IY6:T Acetylation_K 137 P13984 137 T2FB_HUMAN Homo sapiens (Human)
5IY6:T Acetylation_K 33 P13984 33 T2FB_HUMAN Homo sapiens (Human)
5IY6:T Acetylation_K 22 P13984 22 T2FB_HUMAN Homo sapiens (Human)
5IY6:T Phosphorylation_S 142 P13984 142 T2FB_HUMAN Homo sapiens (Human)
5IY6:T Phosphorylation_Y 165 P13984 165 T2FB_HUMAN Homo sapiens (Human)
5IY6:T Phosphorylation_Y 124 P13984 124 T2FB_HUMAN Homo sapiens (Human)
5IY6:T Ubiquitylation_K 154 P13984 154 T2FB_HUMAN Homo sapiens (Human)
5IY6:T Ubiquitylation_K 137 P13984 137 T2FB_HUMAN Homo sapiens (Human)
5IY6:T Ubiquitylation_K 147 P13984 147 T2FB_HUMAN Homo sapiens (Human)
5IY6:T Ubiquitylation_K 13 P13984 13 T2FB_HUMAN Homo sapiens (Human)
5IY6:T Ubiquitylation_K 200 P13984 200 T2FB_HUMAN Homo sapiens (Human)
5IY6:T Malonylation_K 154 P13984 154 T2FB_HUMAN Homo sapiens (Human)

Mutations affecting PTM Sites

Cancer mutations affecting PTM Sites
gene refseq mutation
Position
mutation
Alt
mutation
Summary
site Position site Residue uniprot ACC uniprot ID
GTF2F2 NM_004128 164 V HNSC 165 Y P13984 T2FB_HUMAN
GTF2F2 NM_004128 122 K BLCA 124 Y P13984 T2FB_HUMAN
GTF2F2 NM_004128 164 A KIRC 165 Y P13984 T2FB_HUMAN
GTF2F2 NM_004128 135 C BLCA 137 K P13984 T2FB_HUMAN
GTF2F2 NM_004128 135 C BLCA 142 S P13984 T2FB_HUMAN


Population mutations affecting PTM Sites
gene refseq mutation
Position
mutation
Alt
mutation
Summary
site Position site Residue uniprot ACC uniprot ID
GTF2F2 NM_004128 158 S 0.0154 154 K P13984 T2FB_HUMAN
GTF2F2 NM_004128 158 S 0.0154 165 Y P13984 T2FB_HUMAN

Secondary structure features calculated by DSSP

DSSPS results
PTM Position in Chain TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA
2 0.000 360.0 360.0 360.0 96.7 242.7 200.6 193.9
137 -0.780 78.2 -118.1 -133.6 177.7 214.4 239.4 179.9
33 -0.074 89.1 174.5 -96.5 29.0 222.5 220.2 169.5
22 -0.717 24.2 -173.3 -82.2 128.5 238.2 228.1 173.1
142 -0.715 23.3 -169.2 -92.0 94.7 209.8 247.8 187.7
165 0.891 99.7 51.9 -58.5 -47.1 191.6 228.2 218.8
124 0.326 108.7 85.8 -166.9 -34.4 228.6 243.8 164.8
154 -0.802 15.3 -157.8 -88.9 120.5 188.8 241.8 207.7
147 -0.123 64.4 174.3 135.6 127.6 197.5 251.3 189.7
13 0.687 111.3 51.4 -71.9 -19.3 253.6 208.7 181.6
200 0.875 109.2 49.5 -59.6 -39.8 211.1 225.1 233.0

Relative accessibilities features calculated by NACCESS

NACCESSES results
PTM Position
in Chain
All-atoms Total-Side Main-Chain Non-polar All-polar
ABS REL ABS REL ABS REL ABS REL ABS REL
2 674.91 625.2 462.80 666.8 212.11 550.4 462.80 648.4 212.11 579.9
137 12.47 6.2 12.47 7.6 0.00 0.0 0.00 0.0 12.47 14.8
33 294.47 146.6 294.47 180.3 0.00 0.0 0.00 0.0 294.47 349.6
22 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0
142 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0
165 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0
124 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0
154 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0
147 11.19 5.6 11.19 6.9 0.00 0.0 0.00 0.0 11.19 13.3
13 115.48 57.5 77.98 47.8 37.50 100.0 12.14 10.4 103.34 122.7
200 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0

Protein Feature View

Sequence Alignment

Disorder picture

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Sequence view