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Detailed Infomation


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  • PDB: 4X45

  • Chain: A

  • Protein Name: Adenine phosphoribosyltransferase

  • GeneName: APRT

  • Resolution: 1.75 Å
  •        Method: X-RAY DIFFRACTION
PTM Information
PDBChain PTM Type PTM Position
in PDBChain
UniProt ACC PTM Position UniProtID Organism
4X45:A Acetylation_A 2 P07741 2 APT_HUMAN Homo sapiens (Human)
4X45:A Acetylation_K 114 P07741 114 APT_HUMAN Homo sapiens (Human)
4X45:A Phosphorylation_S 66 P07741 66 APT_HUMAN Homo sapiens (Human)
4X45:A Phosphorylation_S 30 P07741 30 APT_HUMAN Homo sapiens (Human)
4X45:A Phosphorylation_S 15 P07741 15 APT_HUMAN Homo sapiens (Human)
4X45:A Phosphorylation_S 100 P07741 100 APT_HUMAN Homo sapiens (Human)
4X45:A Phosphorylation_T 135 P07741 135 APT_HUMAN Homo sapiens (Human)
4X45:A Phosphorylation_Y 60 P07741 60 APT_HUMAN Homo sapiens (Human)
4X45:A Ubiquitylation_K 114 P07741 114 APT_HUMAN Homo sapiens (Human)
4X45:A Ubiquitylation_K 167 P07741 167 APT_HUMAN Homo sapiens (Human)
4X45:A Ubiquitylation_K 34 P07741 34 APT_HUMAN Homo sapiens (Human)
4X45:A Malonylation_K 114 P07741 114 APT_HUMAN Homo sapiens (Human)

Mutations affecting PTM Sites

Cancer mutations affecting PTM Sites
gene refseq mutation
Position
mutation
Alt
mutation
Summary
site Position site Residue uniprot ACC uniprot ID
APRT NM_001030018 9 I SARC 15 S P07741 APT_HUMAN
APRT NM_000485 9 I SARC 15 S P07741 APT_HUMAN
APRT NM_000485 121 H LUAD 114 K P07741 APT_HUMAN
APRT NM_001030018 121 H LUAD 114 K P07741 APT_HUMAN
APRT NM_000485 166 K CESC 167 K P07741 APT_HUMAN
APRT NM_000485 132 A STAD 135 T P07741 APT_HUMAN


Disease mutations affecting PTM Sites
gene refseq mutation
Position
mutation
Alt
mutation
Summary
site Position site Residue uniprot ACC uniprot ID
APRT NM_000485 136 T Adenine phosphoribosyltransferase deficiency, APRT deficiency, Japanese type 135 T P07741 APT_HUMAN
APRT NM_000485 110 P Adenine phosphoribosyltransferase deficiency 114 K P07741 APT_HUMAN
APRT NM_001030018 110 P Adenine phosphoribosyltransferase deficiency 114 K P07741 APT_HUMAN
APRT NM_000485 65 V Adenine phosphoribosyltransferase deficiency 66 S P07741 APT_HUMAN
APRT NM_000485 65 V Adenine phosphoribosyltransferase deficiency 60 Y P07741 APT_HUMAN
APRT NM_001030018 65 V Adenine phosphoribosyltransferase deficiency 66 S P07741 APT_HUMAN
APRT NM_001030018 65 V Adenine phosphoribosyltransferase deficiency 60 Y P07741 APT_HUMAN


Population mutations affecting PTM Sites
gene refseq mutation
Position
mutation
Alt
mutation
Summary
site Position site Residue uniprot ACC uniprot ID
APRT NM_000485 174 C 0.0077 167 K P07741 APT_HUMAN
APRT NM_000485 173 L 0.0077 167 K P07741 APT_HUMAN
APRT NM_000485 167 N 0.0077 167 K P07741 APT_HUMAN
APRT NM_000485 121 R 0.1385 114 K P07741 APT_HUMAN
APRT NM_001030018 121 R 0.1385 114 K P07741 APT_HUMAN
APRT NM_000485 118 Q 0.0077 114 K P07741 APT_HUMAN
APRT NM_001030018 118 Q 0.0077 114 K P07741 APT_HUMAN
APRT NM_000485 116 T 0.0231 114 K P07741 APT_HUMAN
APRT NM_001030018 116 T 0.0231 114 K P07741 APT_HUMAN
APRT NM_000485 114 T 0.0616 114 K P07741 APT_HUMAN
APRT NM_001030018 114 T 0.0616 114 K P07741 APT_HUMAN
APRT NM_000485 110 P 0.0077 114 K P07741 APT_HUMAN
APRT NM_001030018 110 P 0.0077 114 K P07741 APT_HUMAN
APRT NM_000485 62 V 0.1448 66 S P07741 APT_HUMAN
APRT NM_000485 62 V 0.1448 60 Y P07741 APT_HUMAN
APRT NM_001030018 62 V 0.1448 66 S P07741 APT_HUMAN
APRT NM_001030018 62 V 0.1448 60 Y P07741 APT_HUMAN
APRT NM_000485 57 L 0.0079 60 Y P07741 APT_HUMAN
APRT NM_001030018 57 L 0.0079 60 Y P07741 APT_HUMAN
APRT NM_000485 31 L 0.0079 30 S P07741 APT_HUMAN
APRT NM_000485 31 L 0.0079 34 K P07741 APT_HUMAN
APRT NM_001030018 31 L 0.0079 34 K P07741 APT_HUMAN
APRT NM_001030018 31 L 0.0079 30 S P07741 APT_HUMAN
APRT NM_000485 121 R 0.00159744 114 K P07741 APT_HUMAN
APRT NM_001030018 121 R 0.00159744 114 K P07741 APT_HUMAN
APRT NM_000485 116 T 0.000399361 114 K P07741 APT_HUMAN
APRT NM_001030018 116 T 0.000399361 114 K P07741 APT_HUMAN
APRT NM_000485 114 T 0.000599042 114 K P07741 APT_HUMAN
APRT NM_001030018 114 T 0.000599042 114 K P07741 APT_HUMAN
APRT NM_000485 110 V 0.000199681 114 K P07741 APT_HUMAN
APRT NM_001030018 110 V 0.000199681 114 K P07741 APT_HUMAN
APRT NM_000485 62 V 0.00259585 66 S P07741 APT_HUMAN
APRT NM_000485 62 V 0.00259585 60 Y P07741 APT_HUMAN
APRT NM_001030018 62 V 0.00259585 66 S P07741 APT_HUMAN
APRT NM_001030018 62 V 0.00259585 60 Y P07741 APT_HUMAN
APRT NM_000485 31 L 0.000199681 30 S P07741 APT_HUMAN
APRT NM_000485 31 L 0.000199681 34 K P07741 APT_HUMAN
APRT NM_001030018 31 L 0.000199681 34 K P07741 APT_HUMAN
APRT NM_001030018 31 L 0.000199681 30 S P07741 APT_HUMAN

Secondary structure features calculated by DSSP

DSSPS results
PTM Position in Chain TCO KAPPA ALPHA PHI PSI X-CA Y-CA Z-CA
2 0.000 360.0 360.0 360.0 -112.3 -1.2 -9.6 23.7
114 0.753 109.8 44.1 -60.8 -25.8 -4.6 30.4 4.7
66 -0.898 132.4 25.0 -117.7 -31.1 -5.5 18.2 20.3
30 0.850 73.9 55.7 -51.5 -43.8 -3.5 6.9 26.9
15 -0.777 18.5 -178.0 -98.8 129.1 -12.7 2.0 29.5
100 -0.565 24.3 173.9 -94.8 158.4 -17.8 26.4 13.7
135 0.882 115.2 51.4 -67.4 -39.5 -14.5 18.5 14.3
60 -0.984 52.6 -135.0 -143.5 151.6 -0.3 15.6 3.5
167 0.754 98.4 60.7 -71.8 -25.0 -22.1 13.0 8.6
34 0.799 99.9 63.3 -72.5 -31.1 2.4 4.7 27.0

Relative accessibilities features calculated by NACCESS

NACCESSES results
PTM Position
in Chain
All-atoms Total-Side Main-Chain Non-polar All-polar
ABS REL ABS REL ABS REL ABS REL ABS REL
2 286.81 265.7 0.00 0.0 286.81 744.2 0.00 0.0 286.81 784.1
114 261.96 130.5 261.96 160.4 0.00 0.0 5.05 4.3 256.91 305.0
66 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0
30 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0
15 15.55 13.3 15.55 19.9 0.00 0.0 15.55 32.0 0.00 0.0
100 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0
135 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0
60 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0
167 152.32 75.9 152.32 93.3 0.00 0.0 152.32 130.7 0.00 0.0
34 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0 0.00 0.0

Protein Feature View

Sequence Alignment

Mutation Information

P07741
Maingenename SwissProtAC FTId AAchange Typeofvariant dbSNP Diseasename
APRT P07741 VAR_006747 p.Asp65Val Disease rs104894506 Adenine phosphoribosyltransferase deficiency (APRTD) [MIM:614723]
APRT P07741 VAR_006748 p.Leu110Pro Disease rs104894508 Adenine phosphoribosyltransferase deficiency (APRTD) [MIM:614723]
APRT P07741 VAR_006749 p.Met136Thr Disease rs28999113 Adenine phosphoribosyltransferase deficiency (APRTD) [MIM:614723]
APRT P07741 VAR_019055 p.Gln121Arg Polymorphism rs8191494 -
APRT P07741 VAR_022608 p.Val150Phe Disease rs281860266 Adenine phosphoribosyltransferase deficiency (APRTD) [MIM:614723]
APRT P07741 VAR_022609 p.Cys153Arg Disease - Adenine phosphoribosyltransferase deficiency (APRTD) [MIM:614723]
APRT P07741 VAR_069049 p.Leu33Pro Disease - Adenine phosphoribosyltransferase deficiency (APRTD) [MIM:614723]
APRT P07741 VAR_069050 p.Val84Met Disease rs200392753 Adenine phosphoribosyltransferase deficiency (APRTD) [MIM:614723]
APRT P07741 VAR_069051 p.Gly133Asp Disease - Adenine phosphoribosyltransferase deficiency (APRTD) [MIM:614723]

Disorder picture

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Sequence view