PTM Information

PDBChain	PTM Type	PTM Position in PDBChain	UniProt ACC	PTM Position	UniProtID	Organism
4X45:A	Acetylation_A	2	P07741	2	APT_HUMAN	Homo sapiens (Human)
4X45:A	Acetylation_K	114	P07741	114	APT_HUMAN	Homo sapiens (Human)
4X45:A	Phosphorylation_S	66	P07741	66	APT_HUMAN	Homo sapiens (Human)
4X45:A	Phosphorylation_S	30	P07741	30	APT_HUMAN	Homo sapiens (Human)
4X45:A	Phosphorylation_S	15	P07741	15	APT_HUMAN	Homo sapiens (Human)
4X45:A	Phosphorylation_S	100	P07741	100	APT_HUMAN	Homo sapiens (Human)
4X45:A	Phosphorylation_T	135	P07741	135	APT_HUMAN	Homo sapiens (Human)
4X45:A	Phosphorylation_Y	60	P07741	60	APT_HUMAN	Homo sapiens (Human)
4X45:A	Ubiquitylation_K	114	P07741	114	APT_HUMAN	Homo sapiens (Human)
4X45:A	Ubiquitylation_K	167	P07741	167	APT_HUMAN	Homo sapiens (Human)
4X45:A	Ubiquitylation_K	34	P07741	34	APT_HUMAN	Homo sapiens (Human)
4X45:A	Malonylation_K	114	P07741	114	APT_HUMAN	Homo sapiens (Human)

Cancer mutations affecting PTM Sites

gene	refseq	mutation Position	mutation Alt	mutation Summary	site Position	site Residue	uniprot ACC	uniprot ID
APRT	NM_001030018	9	I	SARC	15	S	P07741	APT_HUMAN
APRT	NM_000485	9	I	SARC	15	S	P07741	APT_HUMAN
APRT	NM_000485	121	H	LUAD	114	K	P07741	APT_HUMAN
APRT	NM_001030018	121	H	LUAD	114	K	P07741	APT_HUMAN
APRT	NM_000485	166	K	CESC	167	K	P07741	APT_HUMAN
APRT	NM_000485	132	A	STAD	135	T	P07741	APT_HUMAN

Disease mutations affecting PTM Sites

gene	refseq	mutation Position	mutation Alt	mutation Summary	site Position	site Residue	uniprot ACC	uniprot ID
APRT	NM_000485	136	T	Adenine phosphoribosyltransferase deficiency, APRT deficiency, Japanese type	135	T	P07741	APT_HUMAN
APRT	NM_000485	110	P	Adenine phosphoribosyltransferase deficiency	114	K	P07741	APT_HUMAN
APRT	NM_001030018	110	P	Adenine phosphoribosyltransferase deficiency	114	K	P07741	APT_HUMAN
APRT	NM_000485	65	V	Adenine phosphoribosyltransferase deficiency	66	S	P07741	APT_HUMAN
APRT	NM_000485	65	V	Adenine phosphoribosyltransferase deficiency	60	Y	P07741	APT_HUMAN
APRT	NM_001030018	65	V	Adenine phosphoribosyltransferase deficiency	66	S	P07741	APT_HUMAN
APRT	NM_001030018	65	V	Adenine phosphoribosyltransferase deficiency	60	Y	P07741	APT_HUMAN

Population mutations affecting PTM Sites

gene	refseq	mutation Position	mutation Alt	mutation Summary	site Position	site Residue	uniprot ACC	uniprot ID
APRT	NM_000485	174	C	0.0077	167	K	P07741	APT_HUMAN
APRT	NM_000485	173	L	0.0077	167	K	P07741	APT_HUMAN
APRT	NM_000485	167	N	0.0077	167	K	P07741	APT_HUMAN
APRT	NM_000485	121	R	0.1385	114	K	P07741	APT_HUMAN
APRT	NM_001030018	121	R	0.1385	114	K	P07741	APT_HUMAN
APRT	NM_000485	118	Q	0.0077	114	K	P07741	APT_HUMAN
APRT	NM_001030018	118	Q	0.0077	114	K	P07741	APT_HUMAN
APRT	NM_000485	116	T	0.0231	114	K	P07741	APT_HUMAN
APRT	NM_001030018	116	T	0.0231	114	K	P07741	APT_HUMAN
APRT	NM_000485	114	T	0.0616	114	K	P07741	APT_HUMAN
APRT	NM_001030018	114	T	0.0616	114	K	P07741	APT_HUMAN
APRT	NM_000485	110	P	0.0077	114	K	P07741	APT_HUMAN
APRT	NM_001030018	110	P	0.0077	114	K	P07741	APT_HUMAN
APRT	NM_000485	62	V	0.1448	66	S	P07741	APT_HUMAN
APRT	NM_000485	62	V	0.1448	60	Y	P07741	APT_HUMAN
APRT	NM_001030018	62	V	0.1448	66	S	P07741	APT_HUMAN
APRT	NM_001030018	62	V	0.1448	60	Y	P07741	APT_HUMAN
APRT	NM_000485	57	L	0.0079	60	Y	P07741	APT_HUMAN
APRT	NM_001030018	57	L	0.0079	60	Y	P07741	APT_HUMAN
APRT	NM_000485	31	L	0.0079	30	S	P07741	APT_HUMAN
APRT	NM_000485	31	L	0.0079	34	K	P07741	APT_HUMAN
APRT	NM_001030018	31	L	0.0079	34	K	P07741	APT_HUMAN
APRT	NM_001030018	31	L	0.0079	30	S	P07741	APT_HUMAN
APRT	NM_000485	121	R	0.00159744	114	K	P07741	APT_HUMAN
APRT	NM_001030018	121	R	0.00159744	114	K	P07741	APT_HUMAN
APRT	NM_000485	116	T	0.000399361	114	K	P07741	APT_HUMAN
APRT	NM_001030018	116	T	0.000399361	114	K	P07741	APT_HUMAN
APRT	NM_000485	114	T	0.000599042	114	K	P07741	APT_HUMAN
APRT	NM_001030018	114	T	0.000599042	114	K	P07741	APT_HUMAN
APRT	NM_000485	110	V	0.000199681	114	K	P07741	APT_HUMAN
APRT	NM_001030018	110	V	0.000199681	114	K	P07741	APT_HUMAN
APRT	NM_000485	62	V	0.00259585	66	S	P07741	APT_HUMAN
APRT	NM_000485	62	V	0.00259585	60	Y	P07741	APT_HUMAN
APRT	NM_001030018	62	V	0.00259585	66	S	P07741	APT_HUMAN
APRT	NM_001030018	62	V	0.00259585	60	Y	P07741	APT_HUMAN
APRT	NM_000485	31	L	0.000199681	30	S	P07741	APT_HUMAN
APRT	NM_000485	31	L	0.000199681	34	K	P07741	APT_HUMAN
APRT	NM_001030018	31	L	0.000199681	34	K	P07741	APT_HUMAN
APRT	NM_001030018	31	L	0.000199681	30	S	P07741	APT_HUMAN

DSSPS results

PTM Position in Chain	TCO	KAPPA	ALPHA	PHI	PSI	X-CA	Y-CA	Z-CA
2	0.000	360.0	360.0	360.0	-112.3	-1.2	-9.6	23.7
114	0.753	109.8	44.1	-60.8	-25.8	-4.6	30.4	4.7
66	-0.898	132.4	25.0	-117.7	-31.1	-5.5	18.2	20.3
30	0.850	73.9	55.7	-51.5	-43.8	-3.5	6.9	26.9
15	-0.777	18.5	-178.0	-98.8	129.1	-12.7	2.0	29.5
100	-0.565	24.3	173.9	-94.8	158.4	-17.8	26.4	13.7
135	0.882	115.2	51.4	-67.4	-39.5	-14.5	18.5	14.3
60	-0.984	52.6	-135.0	-143.5	151.6	-0.3	15.6	3.5
167	0.754	98.4	60.7	-71.8	-25.0	-22.1	13.0	8.6
34	0.799	99.9	63.3	-72.5	-31.1	2.4	4.7	27.0

NACCESSES results

PTM Position in Chain	All-atoms		Total-Side		Main-Chain		Non-polar		All-polar
	ABS	REL	ABS	REL	ABS	REL	ABS	REL	ABS	REL
2	286.81	265.7	0.00	0.0	286.81	744.2	0.00	0.0	286.81	784.1
114	261.96	130.5	261.96	160.4	0.00	0.0	5.05	4.3	256.91	305.0
66	0.00	0.0	0.00	0.0	0.00	0.0	0.00	0.0	0.00	0.0
30	0.00	0.0	0.00	0.0	0.00	0.0	0.00	0.0	0.00	0.0
15	15.55	13.3	15.55	19.9	0.00	0.0	15.55	32.0	0.00	0.0
100	0.00	0.0	0.00	0.0	0.00	0.0	0.00	0.0	0.00	0.0
135	0.00	0.0	0.00	0.0	0.00	0.0	0.00	0.0	0.00	0.0
60	0.00	0.0	0.00	0.0	0.00	0.0	0.00	0.0	0.00	0.0
167	152.32	75.9	152.32	93.3	0.00	0.0	152.32	130.7	0.00	0.0
34	0.00	0.0	0.00	0.0	0.00	0.0	0.00	0.0	0.00	0.0

P07741

Maingenename	SwissProtAC	FTId	AAchange	Typeofvariant	dbSNP	Diseasename
APRT	P07741	VAR_006747	p.Asp65Val	Disease	rs104894506	Adenine phosphoribosyltransferase deficiency (APRTD) [MIM:614723]
APRT	P07741	VAR_006748	p.Leu110Pro	Disease	rs104894508	Adenine phosphoribosyltransferase deficiency (APRTD) [MIM:614723]
APRT	P07741	VAR_006749	p.Met136Thr	Disease	rs28999113	Adenine phosphoribosyltransferase deficiency (APRTD) [MIM:614723]
APRT	P07741	VAR_019055	p.Gln121Arg	Polymorphism	rs8191494	-
APRT	P07741	VAR_022608	p.Val150Phe	Disease	rs281860266	Adenine phosphoribosyltransferase deficiency (APRTD) [MIM:614723]
APRT	P07741	VAR_022609	p.Cys153Arg	Disease	-	Adenine phosphoribosyltransferase deficiency (APRTD) [MIM:614723]
APRT	P07741	VAR_069049	p.Leu33Pro	Disease	-	Adenine phosphoribosyltransferase deficiency (APRTD) [MIM:614723]
APRT	P07741	VAR_069050	p.Val84Met	Disease	rs200392753	Adenine phosphoribosyltransferase deficiency (APRTD) [MIM:614723]
APRT	P07741	VAR_069051	p.Gly133Asp	Disease	-	Adenine phosphoribosyltransferase deficiency (APRTD) [MIM:614723]

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